快速访问

查看PDF

文章信息

参考文献

[1]中国骨关节炎诊疗指南专家组, 中国老年保健协会疼痛病学分会, 黄东, 等. 中国骨关节炎诊疗指南(2024版) [J]. 中华疼痛学杂志, 2024, 20(3): 323-338.
[2]SAFIRI S, KOLAHI A A, SMITH E, et al. Global, regional and national burden of osteoarthritis 1990-2017: a systematic analysis of the Global Burden of Disease Study 2017 [J].  Annals of the Rheumatic Diseases, 2020, 79(6): 819-828. DOI: 10.1136/annrheumdis-2019-216515.
[3]GBD 2021 DISEASES AND INJURIES COLLABORATORS. Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021 [J]. Lancet, 2024, 403(10440): 2133-2161. DOI: 10.1016/S0140-6736(24)00757-8.
[4]GIORGINO R, ALBANO D, FUSCO S, et al. Knee osteoarthritis: epidemiology, pathogenesis, and mesenchymal stem cells: what else is new? an update [J]. International Journal of Molecular Sciences, 2023, 24(7): 6405. DOI: 10.3390/ijms24076405.
[5]冯晓晴, 蔡道章, 余星磊, 等. 基于GBD大数据中国膝骨关节炎疾病负担现状与趋势分析 [J]. 现代预防医学, 2022, 49(10): 1753-1760.
[6]HOCHBERG C M, ALTMAN D R, APRIL T K, et al.American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. [J]. Arthritis care & research, 2012, 64(4): 465-474.DOI: 10.1002/ACR.21596.
[7]清·张锡纯. 医学衷中参西录 [M]. 太原: 山西科学技术出版社, 2009: 353.
[8]陶韬. 加味曲直汤治疗膝关节骨性关节炎的临床疗效观察 [D]. 南京中医药大学, 2020. DOI: 10.27253/d.cnki.gnjzu.2020.000571.
[9]刘小宝, 林昌松. 张锡纯治疗痹病经验探析 [J]. 江西中医药, 2019, 50(10): 18-20.
[10]贾瑞雪, 刘妍君, 凌婷婷, 等.《医学衷中参西录》肝气虚辨治特色探析 [J]. 江苏中医药, 2023, 55(9): 76-78. DOI: 10.19844/j.cnki.1672-397X.2023.09.020.
[11]韩政云, 商庆新. 张锡纯肝虚腿疼理论治疗脑梗死合并不安腿综合征理论索解 [J]. 环球中医药, 2021, 14(5): 864-866.
[12]管玉洁, 何晓瑾, 周学平, 等. 国医大师周仲瑛从络病论治骨关节炎经验 [J]. 南京中医药大学学报, 2021, 37(2): 287-289.DOI: 10.14148/j.issn.1672-0482.2021.0287.
[13]OLIVEIRA D R M, NABAVI M S, BRAIDY N, et al. Quercetin and the mitochondria: A mechanistic view [J]. Biotechnology Advances, 2016, 34(5): 532-549. DOI: 10.1016/j.biotechadv.2015.12.014.
[14]MILADPOUR B, RASTI M, OWJI A A, et al. Quercetin potentiates transdifferentiation of bone marrow mesenchymal stem cells into the beta cells in vitro. [J]. Journal of endocrinological investigation, 2017, 40(5): 513-521. DOI: 10.1007/s40618-016-0592-8.
[15]ZHOU Y, WU Y, JIANG X, et al. The Effect of Quercetin on the Osteogenesic Differentiation and Angiogenic Factor Expression of Bone Marrow-Derived Mesenchymal Stem Cells. [J]. PLoS ONE, 2017, 10(6): e0129605. DOI: 10.1371/journal.pone.0129605.
[16]朱保红, 柴喜平, 徐斌, 等. 槲皮素治疗膝骨关节炎的相关分子机制研究进展 [J]. 湖北民族大学学报(医学版), 2024, 41(3): 89-93+99. DOI: 10.13501/j.cnki.42-1590/r.2024.03.017.
[17]DING J, YANG C, LI X. Phosphatase and tensin homolog accelerate the inflammatory injury and glycolysis of chondrocytes through TP53 protein-mediated p38MAPK pathway activation in a high-glucose environment. [J]. CytoJournal, 2025, 2275. DOI: 10.25259/CYTOJOURNAL_199_2024.
[18]ZHAO S, XU H, CHEN J, et al. Key Role of STAT3 in Osteoarthritis: From Pathogenic Mechanisms to Targeted Therapy. [J]. International journal of nanomedicine, 2025, 2014075-14096. DOI: 10.2147/IJN.S558209.
[19]SUN K, LUO J, GUO J, et al. The PI3K/AKT/mTOR signaling pathway in osteoarthritis: a narrative review [J]. Osteoarthritis and Cartilage, 2020, 28(prepublish): 400-409. DOI: 10.1016/j.joca.2020.02.027.
[20]KEJIE W, MINJIE C, FENG W, et al. Putative functional variants of PI3K/AKT/mTOR pathway are associated with knee osteoarthritis susceptibility. [J]. Journal of clinical laboratory analysis, 2020, 34(6): e23240. DOI: 10.1002/jcla.23240.
[21]LAURA B, ANITA W, G C J, et al. Src kinase inhibition promotes the chondrocyte phenotype [J]. Arthritis research & therapy, 2007, 9(5): R105. DOI: 10.1186/ar2308.
[22]RONG G, ZHANG Z, ZHAN W, et al. VEGFA, MYC, and JUN are abnormally elevated in the synovial tissue of patients with advanced osteoarthritis [J]. Scientific Reports, 2025, 15(1): 2066-2066. DOI: 10.1038/S41598-024-80551-7.
[23]XU L, MA J, ZhOU C, et al. Identification of key hub genes in knee osteoarthritis through integrated bioinformatics analysis. [J]. Scientific reports, 2024, 14(1): 22437. DOI: 10.1038/S41598-024-73188-Z.
[24]潘雪洁, 陆卉, 李磊. 槲皮素靶向PI3K/AKT信号通路延缓骨髓间充质干细胞衰老 [J]. 西部医学, 2025, 37(8): 1109-1114.
[25]RUI Z, XIAOQIN D, QUAN L, et al. Global research trends and hotspots of PI3K/Akt signaling pathway in the field of osteoarthritis: A bibliometric study. [J]. Medicine, 2023, 102(15): e33489-e33489. DOI: 10.1097/MD.0000000000033489.
[26]FAN Q, ZHAO M, ZHANG D X, et al. Research progress and prospect of MAPK signaling pathway in knee osteoarthritis [J]. European Journal of Orthopaedic Surgery & Traumatology, 2025, 35(1): 134-134. DOI: 10.1007/S00590-025-04261-0.
[27]RAVICHANDRAM R, FANG S Y, MARIE A S. Receptor for AGE (RAGE): signaling mechanisms in the pathogenesis of diabetes and its complications. [J]. Annals of the New York Academy of Sciences, 2011, 1243(1): 88-102. DOI: 10.1111/j.1749-6632.2011.06320.x.
[28]ZHAO-JUN W, HAI-BIN Z, CHENG C, et al. Effect of PPARG on AGEs-induced AKT/MTOR signaling-associated human chondrocytes autophagy. [J]. Cell biology international, 2018, 42(7): 841-848. DOI: 10.1002/cbin.10951.

版权与开放获取声明

作为一本开放获取的学术期刊,所有文章均遵循 Creative Commons Attribution 4.0 International License (CC BY 4.0) 协议发布,允许用户在署名原作者的前提下自由共享与再利用内容。所有文章均可免费供读者和机构阅读、下载、引用与传播,EWA Publishing 不会通过期刊的出版发行向读者或机构收取任何费用。